KLAHN, PHILIPP,BRONSTRUP, MARK,FETZ, VERENA,COLLISI, WERA,MOHR, KATRIN I.,HUTTEL, STEPHAN,TEGGE, WERNER
申请号：
CA3072399
公开号：
CA3072399A1
申请日:
2018.08.08
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.
