The present disclosure provides for a syringe that is designed to enable a plunger to be locked or secured in position thereby freeing a user's hand from the plunger for other tasks. The syringe may be coupled to a needle or hypodermic needle or other apparatus such as an intravenous line/port or catheter. The syringe takes advantage of a tapered barrel and a positive stop to prevent movement of the piston along the inner surface of the barrel when no force is being actively applied to the plunger. This prevents unwanted suction or spillage of the contents contained therein.