(57)< Abstract > The medicine composition which includes the acidic medicine which is discharged uniformly than covering in the wide-ranging pH value encountering between the stomach and the intestinal tract includes, the acidic medicine approximately 10 - approximately 40 weight % the neutral water swelling hydrophilic polymer and 20 - approximately 50 weight % at the pH value which approximately exceeds 5 in the water in the matrix which consists of the acid dissolved polymer which swelling is done melting or dispersing, or. Especially the desirable composition includes jibarupuroetsukusunatoriumu. Before the tablet converting before the granule, and the tablet conversion also production method of unit medicine type of the granule and the tablet is disclosed.胃と腸管の間で出会う広範囲のpH値にわたりより均一に放出される酸性薬物を含む医薬組成物は、酸性薬物を約10~約40重量%の中性水膨潤性親水性ポリマー及び20~約50重量%の約5を越えるpH値で水に膨潤する酸溶解性ポリマーからなるマトリックスに溶解または分散して含む。特に好ましい組成物はジバルプロエックスナトリウムを含む。錠剤化前顆粒、並びに錠剤化前顆粒及び錠剤の単位剤型の製造方法をも開示する。
