The present invention relates to a method and system for selecting a customized drug using information of cancer genomic nucleotide sequence variations and patient survival and, more specifically, to a method and system for selecting a customized anticancer therapeutic drug using variation information of a synthetic cancer survival gene among cancer genomic nucleotide sequence variations. The method and system for customized anticancer therapy of the present invention using information of cancer genomic mutations and patient survival or the evaluation of invasive or metastatic ability of cancer cells or tissues correspond to a technique to effectively select an anticancer therapeutic drug having a good therapeutic effect and prognosis according to the individual through the variation analysis of synthetic cancer survival gene pairs, which is derived from the information of cancer genomic nucleotide sequence variations and cancer survival and metastasis, and the method and system of the present invention have