胱胺酸結骨架平臺农业专利-农业学术服务平台

发明人:: HANNOUSH, RAMI,汉那许　拉米,漢那許　拉米,KALUARACHCHI, HARINI,卡邬亚拉启齐　哈里尼,卡鄔亞拉啟齊　哈里尼,NILE, AARON,尼尔　亚伦,尼爾　亞倫,NOLAND, CAMERON,诺兰　卡麦隆,諾蘭　卡麥隆,ZHANG, YINGNAN,张映楠,張映楠,ZHOU, LIJUAN,周丽娟,周麗娟,GAO, XINXIN,高新欣,汉那许拉米,漢那許拉米,卡邬亚拉启齐哈里尼,卡鄔亞拉啟齊哈里尼,尼尔亚伦,尼爾亞倫,诺兰卡麦隆,諾蘭卡麥隆

摘要：: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.本發明提供可結合VEGF-A之非天然存在之胱胺酸結肽(CKP)。另外，提供使用可結合VEGF-A之非天然存在之CKP的方法，包括診斷性及治療性組合物及方法。亦提供可結合低密度脂蛋白受體相關蛋白6(LRP6)之非天然CKP。