Szu-Yao Kuo;Han-Chung Wu;Chin-Tarng Lin;Tong-Young Lee
发明人:
Han-Chung Wu,Chin-Tarng Lin,Tong-Young Lee,Szu-Yao Kuo
申请号：
US11783926
公开号：
US08088887B2
申请日:
2007.04.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.
