Christiaan Peter Maria Reutelingsperger;Adriaan Thomas Vermaire;Peter Jozef Jacobus Moonen
发明人:
Christiaan Peter Maria Reutelingsperger,Peter Jozef Jacobus Moonen,Adriaan Thomas Vermaire
申请号：
US13376090
公开号：
US08658768B2
申请日:
2010.06.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
An Annexin A5 variant, comprising one or more RGD (Arg-Gly-Asp) sequences, is suitable for use in the treatment of a disease in mammals, including humans, wherein augmentation of phagocytosis is a desired effect of treatment. The Annexin A5 variant can e.g. be used in the treatment of chronic inflammatory diseases such as atherosclerotic plaque or in the treatment of COPD. At least one RGD sequence may substitute sequences of three amino acids within the range 1-19 or other regions of the amino acid sequences of Annexin A5； alternatively one or more RGD sequences may be part of an extension at the N-terminal side.
