A manufacturing method of a physical multi-impact liquid-state energy water is provided. The manufacturing method includes processing water by a coarse filtering process, a first standing process, a fine filtering process, a second standing process, a centrifugation process, a third standing process and a spiral pressurization process. The physical multi-impact liquid-state energy water is manufactured by repeated multiple impacts, and is water in small molecular groups having micro-vibration element liquid-state energy and having a value of frequency of nuclear magnetic resonance in full width at half maximum under 100 Hz. Water molecular groups of nearby regions are activated by physical resonance to miniaturize the water molecular groups of the nearby regions, in a way that the size of the water molecular groups of the nearby regions is fundamentally changed. The present invention is applicable to various products to promote maintaining body health.