CHATTARAJ SARAT C,REDELMAN GLENN ALLEN,SHAW ANDREW ALAN
申请号：
IN11040DEN2014
公开号：
IN11040DEN2014A
申请日:
2014.12.23
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Various fenofibrate dosage forms contain a plurality of beads or particles where the beads or particles include a pharmaceutical composition comprising fenofibrate； from 0.3% to 10% by weight of the beads or particles of a surfactant； and from about 5% to about 15% by weight of the beads or particles of a water soluble or water dispersible cellulosic binder. The mass ratio of the drug to the binder in the dosage form is between about 3.5:1 and 4.5:1； and the dosage form produces a first Cmax in vivo that is between about 10% and about 50% higher than a comparative Cmax produced by a comparative dosage form. The comparative dosage form comprises the drug and the binder in a ratio of between about 5:1 and 15:1.
