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Oxazolidinone containing dimer compounds, compositions and methods to make and use
专利权人:
TRIUS THERAPEUTICS INC.
发明人:
申请号:
IL23904915
公开号:
IL239049D0
申请日:
2015.05.28
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula (IV) wherein n is a non-negative integer wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR1 or NR1R2 wherein R1 and R2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.
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