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oxazolidinone-containing dimer compounds, compositions and methods for making and using
专利权人:
Trius Therapeutics
发明人:
D. Keith Hester,John Finn,Robert J. Duguid
申请号:
BRPI1012047
公开号:
BRPI1012047A2
申请日:
2010.05.27
申请国别(地区):
BR
年份:
2019
代理人:
摘要:
Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV: wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR1 or NR1R2; wherein R1 and R2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.
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