Florence Dal Degan,Mark J. Newman,Jeffery L. Alexander,Scott Southwood
申请号：
US14978829
公开号：
US09789181B2
申请日:
2015.12.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is H X2 is selected from the group consisting of F, N, Y and W X3 is H and X4 is selected from the group consisting of A, D and E. The invention also relates to large peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
