FRANKLIN, RICHARD,GOLDING, BERNARD T.,TYSON, ROBERT G.
申请号：
AU2010264703
公开号：
AU2010264703A1
申请日:
2010.06.24
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention concerns prodrugs of mexiletine (and mexiletine's active metabolite) with amino acids or peptides and pharmaceutical compositions containing such prodrugs. Methods for providing pain relief, treating arrhythmia, decreasing the adverse GI side effects associated with mexiletine, increasing the bioavailability of mexiletine, and improving the pharmacokinetic reproducibility of mexiletine with the aforementioned prodrugs are also provided. Oligopeptides incorporating lysine or arginine residues attached directly or indirectly through a glycine residue are also described herein.
