HAMAGUCHI WATARU,KINOYAMA ISAO,KOGANEMARU YOHEI,MIYAZAKI TAKEHIRO,KANEKO OSAMU,SEKIOKA RYUICHI,WASHIO TAKUYA,WASHIO TAK
申请号：
PL12741612
公开号：
PL2671869T3
申请日:
2012.02.01
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
[Problem] To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT 5A receptor regulating action. [Means for Solution] It was found that a tetrahydroisoquinoline derivative characterized by a structure in which an acylguanidino group binds to a N atom of a tetrahydroisoquinoline ring or the like, and a cyclic group binds to an unsaturated ring has a potent 5-HT 5A receptor regulating action and an excellent pharmacological action based on the regulating action and also discovered that the tetrahydroisoquinoline derivative is useful as an agent for treating or preventing dementia, schizophrenia, and the like, whereby the present invention has been completed.
