AGENTS DE DEGRADATION DE PROTEINE MDM2

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

WANG, SHAOMENG,LI, YANGBING,YANG, JIULING,AGUILAR, ANGELO,ZHOU, BING,HU, JIANTAO,XU, FUMING,REJ, ROHAN,HAN, XIN

申请号：

CA3020275

公开号：

CA3020275A1

申请日:

2017.04.06

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present disclosure provides compounds represented by Formula I-A: A1- L 1-B1 I-A and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein A1, B1, and L1 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a condition or disorder responsive to degradation of MDM2 protein such as cancer.

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