1,4-DIAZEPINES FUSIONNEES EN TANT QU'AGENTS DE DEGRADATION DE PROTEINES BET

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

WANG, SHAOMENG,HU, YANG,QIN, CHONG,XU, FUMING,HU, JIANTAO,XIANG, WEIGUO,ZHOU, BING

申请号：

CA3036841

公开号：

CA3036841A1

申请日:

2017.09.13

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure provides compounds represented by Formula I: I, and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.

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