Berzosa Rodríguez Xavier,Marquillas Olondriz Francisco
申请号：
US201213984458
公开号：
US8829023(B2)
申请日:
2012.02.10
申请国别(地区):
美国
年份:
2014
代理人:
摘要：
The invention relates to a process for obtaining compounds derived from tetrahydro-β-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine.
