Jonas Boström;Tomas Fex;Leifeng Cheng;Daniel Pettersen;Michael Karle;Peter Schell
发明人:
Jonas Boström,Leifeng Cheng,Tomas Fex,Michael Karle,Daniel Pettersen,Peter Schell
申请号：
US12755010
公开号：
US08415378B2
申请日:
2010.04.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
or a pharmaceutically suitable salt thereof, wherein,R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3,R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile,or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4；wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate；R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring；or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.
