Nucleic acid derivatives having immunostimulatory activity

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专利权人:

塩野義製薬株式会社

发明人:

釘宮 啓,谷野 哲也,関口 光明,三岡 恭典,黒田 典一,中村 淳

申请号：

JP2019508453

公开号：

JP6611298B2

申请日:

2017.03.29

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The purpose of the present invention is to provide, as a nucleic acid derivative having an immunostimulatory activity, a double-stranded oligonucleotide containing a CpG oligonucleotide as mentioned below. An adjuvant comprising a double-stranded oligonucleotide in which a first strand is a CpG oligonucleotide composed of 8 to 50 nucleotides and a second strand is an oligonucleotide composed of 8 to 60 nucleotides and containing a sequence capable of hybridizing with the first strand, wherein a lipid is bonded to the second strand with a linker interposed therebetween.

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