KUGIMIYA, Akira,TANINO, Tetsuya,SEKIGUCHI, Mitsuaki,MITSUOKA, Yasunori,KURODA, Norikazu,NAKAMURA, Jun
申请号：
SG11201908059Y
公开号：
SG11201908059YA
申请日:
2017.03.29
申请国别(地区):
SG
年份:
2019
代理人:
摘要：
The purpose of the present invention is to provide double-stranded oligonucleotides comprising the CpG oligonucleotide mentioned below, as a nucleic acid derivative having an immunostimulatory activity. An adjuvant comprising a double-stranded oligonucleotide, wherein a first strand is a CpG oligonucleotide consisting of 8 to 50 nucleotides, a second strand is an oligonucleotide consisting of 8 to 60 nucleotides and comprising a sequence capable of hybridizing with the first strand, and a lipid 10 binds to the second strand through a linker. 179
