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CHIRAL NUCLEIC ACID ADJUVANT HAVING IMMUNITY INDUCTION ACTIVITY, AND IMMUNITY INDUCTION ACTIVATOR
专利权人:
发明人:
申请号:
EP15737367.1
公开号:
EP3095461A4
申请日:
2015.01.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Problem The purpose of the present invention is to provide: a chiral nucleic acid adjuvant having immunity-inducing activity and an immunity-inducing activator. Solution The present invention relates to an adjuvant which comprises oligonucleotides which comprise two to four sequences each represented by 5-X 1 CpG X 2 -3 and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3 end side of at least two CpG motifs is connected by phosphorothioate linkage, wherein each nucleic acids at 3 end and 5 end of the oligonucleotide is S type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an immunity-inducible activator comprising the adjuvant.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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