pH-SENSITIVE CARRIER AND METHOD FOR PRODUCTION THEREOF, pH-SENSITIVE MEDICINE AND pH-SENSITIVE PHARMACEUTICAL COMPOSITION EACH CONTAINING SAID CARRIER, AND CULTURE METHOD USING SAID pH-SENSITIVE MEDICINE OR SAID pH-SENSITIVE PHARMACEUTICAL COMPOSITION
#$%^&*AU2017216525B220190117.pdf#####Abstract [Object] To provide a pH sensitive carrier which can serve as a carrier for physiologically active substance and is able to develop a membrane disruptive function promoting effect in response to a weakly acidic environment and its preparation method, and also to provide a pH sensitive drug and a pH sensitive drug composition each containing the carrier, and a culture method using the same. [Solution] A pH sensitive carrier which includes at least one pH sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, C27 bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and a-tocopherol, and which is capable of developing a membrane disruptive function promoting effect.1/22 F I G . 1 A pH SENSITIVE AMPHIPATHIC COMPOUND SUBSTANCE pH SENSITIVE CARRIER ~ INTRODUCTION OF PHYSIOLOGICALLY ACTIVE SUBSTANCE pH SENSITIVE DRUG COMPOSITION FIG.1B ENDOSOME CYTOSOL WEAKLY ACIDIC ENVIRONMENT
