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COMPLEXE D'INCLUSION DE SILODOSINE ET CYCLODEXTRINE
专利权人:
RATIOPHARM GMBH
发明人:
RIMKUS, KATRIN,STEFAN, RALPH
申请号:
EP11727468.8
公开号:
EP2585050B1
申请日:
2011.06.27
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The invention relates to a process for the preparation of a pharmaceutical with an inclusion compound of the active substance silodosin or a pharmaceutically acceptable salt thereof and a cyclodextrin, comprising the process step: a) silodosin or a pharmaceutically acceptable salt thereof is brought into contact with a cyclodextrin in the presence of a solvent, giving rise to a silodosin-cyclodextrin inclusion compound; b) the silodosin-cyclodextrin inclusion compound of step a) is mixed with one or more pharmaceutically acceptable additives; c) drying of the product of step a) and/or step b); and d) if appropriate, the dried mixture is optionally further processed with further pharmaceutically acceptable additives to give a unit dose form.
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