DÉRIVÉ SPIROCARBAMATE MACROCYCLIQUE COMME INHIBITEURS DU FACTEUR XIA, COMPOSITIONS PHARMACEUTIQUEMENT ACCEPTABLES ET LEUR UTILISATION

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

申请号：

EP16860557.4

公开号：

EP3371162A4

申请日:

2016.10.24

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention provides a compound of Formula (I) and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds and said stereoisomers, and pharmaceutical compositions thereof, and methods for using said compounds and compositions for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

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