Macrocyclic spirocarbamate derivatives as factor XIa inhibitors, pharmaceutically acceptable compositions and their use

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专利权人:

MERCK SHARP &； DOHME CORP.;Amjad Ali;Yeon-Hee Lim;Jiayi Xu;Wei Zhou

发明人:

Amjad Ali,Yeon-Hee Lim,Jiayi Xu,Wei Zhou

申请号：

US15771136

公开号：

US10344039B2

申请日:

2016.10.24

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention provides a compound of Formula (I) and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds and said stereoisomers, and pharmaceutical compositions thereof, and methods for using said compounds and compositions for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

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