ANDREW K DILGER,DONALD J P PINTO,INDAWATI DE LUCCA,JAMES R CORTE,KUMAR BALASHANMUGA PABBISETTY,LEON M SMITH II,MICHAEL J ORWAT,RUTH R WEXLER,TIANAN FANG,WILLIAM R EWING,WU YANG,YEHENG ZHU,YUFENG WANG
申请号：
BR112016015717
公开号：
BR112016015717A2
申请日:
2015.01.30
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
