Carboxymethyl-group-containing modified hyaluronic acid and/or salt thereof and/or production method for carboxymethyl-group-containing modified hyaluronic acid and/or salt thereof
Shunichi Fujikawa,Yukina Abe,Kazunori Asaoka,Takushi Yoshida
申请号：
US15027841
公开号：
US10155824B2
申请日:
2014.10.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of producing a carboxymethyl-group-containing modified hyaluronic acid and/or a salt thereof includes a step of subjecting, in a water-containing solvent having a temperature of 30° C. or less, a dissolved raw material hyaluronic acid and/or a salt thereof to a reaction with a haloacetic acid and/or a salt thereof, the water-containing solvent including water or a liquid mixture of a water-soluble organic solvent and water, a ratio of the water-soluble organic solvent in the liquid mixture being 60 v/v % or less.
