1,4-oxazepines as inhibitors of bace1 and / or bace2.

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专利权人:

F. HOFFMANN-LA ROCHE AG;SIENA BIOTECH S.P.A.

发明人:

ALEXANDER V. MAYWEG,ANDREW THOMAS,DIDIER ROMBACH,EMANUELE GABELLIERI,HANS HILPERT,HARALD MAUSER,MARK ROGERS-EVANS,THOMAS WOLTERING,WOLFGANG GUBA,WOLFGANG WOSTL

申请号：

BR112013020019

公开号：

BR112013020019A2

申请日:

2012.03.15

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

The present invention relates to 1,4-Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

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