The present invention provides 4 (3 Amino phenyl) 5 6 dihydro 4H [1 3]oxazin 2 ylamines of formula (I) having BACE1 and/or BACE2 inhibitory activity their manufacture pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer s disease and type 2 diabetes.