Hudson Institute of Medical Research;Monash University
发明人:
NOLD, Marcel,NOLD, Claudia,ELLISDON, Andrew,WHISSTOCK, James
申请号：
EP16810615
公开号：
EP3307767A4
申请日:
2016.06.15
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric anti-inflammatory polypeptide comprising an amino acid sequence of an IL-37 monomer, the amino acid sequence having a mutation or modification for preventing the anti-inflammatory peptide from forming a homodimer.
