HUDSON INSTITUTE OF MEDICAL RESEARCH;MONASH UNIVERSITY
发明人:
NOLD, Marcel,NOLD, Claudia,ELLISDON, Andrew,WHISSTOCK, James
申请号：
PH12017550134
公开号：
PH12017550134A1
申请日:
2017.11.28
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric anti-inflammatory polypeptide comprising an amino acid sequence of an IL-37 monomer, the amino acid sequence having a mutation or modification for preventing the anti-inflammatory peptide from forming a homodimer.
