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Influenza A virus vaccines and inhibitors
专利权人:
发明人:
Gaetano T. Montelione,Kalyan Das,Edward Arnold,Li-Chung Ma,Rong Xiao,Robert M. Krug,Karen Y. Twu,Rei-Lin Kuo
申请号:
US14313534
公开号:
US08916519B2
申请日:
2014.06.24
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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