Gaetano T. Montelione,Kalyan Das,Edward Arnold,Li-Chung Ma,Rong Xiao,Robert M. Krug,Karen Y. Twu,Rei-Lin Kuo
申请号：
US14543258
公开号：
US09079944B2
申请日:
2014.11.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
