GHOSH, SHOMIR,ELDER, AMY M,MATTIA, KAREN M,LULY, JAY R,NAKASATO, YOSHISUKE,OHSHIMA, ETSUO,HARRIMAN, GERALDINE C B,CARSON, KENNETH G
申请号：
NZ59648402
公开号：
NZ596484A
申请日:
2002.11.13
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
Disclosed herein is a pharmaceutical composition comprising the (S)-enantiomer and the (R)-enantiomer of 4-(4-chloro-phenyl)-1-{ 3-[7-(1-hydroxy-1-methyl-ethyl)-11H-10-oxa-1-azadibenzo[a,d]cyclohepten-5-ylidene]-propyl} -3,3-dimethyl-piperidin-4-ol or a physiologically acceptable salt thereof, wherein the ratio of (S)-enantiomer to (R)- enantiomer (w/w) in the composition is at least about 2:1. Said composition is useful in treating a disease associated with aberrant leukocyte recruitment, activation, or recruitment and activation such as: arthritis, atherosclerosis, arteriosclerosis, restenosis, ischemia/reperfusion injury, diabetes mellitus, psoriasis, multiple sclerosis, inflammatory bowel disease, rejection of a transplanted organ or tissue, graft versus host disease, allergy and asthma.
