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Peptide for inducing multinucleation in cells, and use therefor
专利权人:
Toagosei Co., Ltd.;National University Corporation Nagoya University
发明人:
Nahoko Baileykobayashi,Tetsuhiko Yoshida,Makoto Sawada
申请号:
US15321247
公开号:
US10112977B2
申请日:
2015.06.22
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Provided are a synthetic peptide having a multinucleation-inducing activity that can cause multinucleation in a target cell, a multinucleation-inducing agent containing this peptide, and a multinucleation induction method that uses this peptide. The synthetic peptide provided by the present invention is an artificially synthesized peptide that contains (A) a membrane-permeable peptide sequence and (B) a multinucleation-inducing peptide sequence, and that can cause multinucleation in at least one type of eukaryotic cell of human origin or non-human mammal origin. The multinucleation-inducing peptide sequence is constituted of an amino acid sequence given by SEQ ID NO: 1 or SEQ ID NO: 2 or a modified amino acid sequence therefrom.
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