Chekler, Eugene Lvovich Piatnitski,Gilbert, Adam Matthew,Unwalla, Rayomand Jal,Verhoest, Patrick Robert,Anderson, James Thomas
申请号：
AU2018203093
公开号：
AU2018203093A1
申请日:
2018.05.03
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018203093A120180524.pdf#####CARBONITRILE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS Abstract The present invention relates to a compound of Formula 1, 2 or 3: R9 R10 R, R1 R1 R8 HO HO Y CR R R 3 N R3 n R2 N A 2A Formula I A4 Formula 2 CN CN R8 0 o z R3 (CR5 R) A Formula 3 CN wherein A is N or -CRo--, where Ro is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is CRe --, or, -N--, where Re is hydrogen, C1-C6 linear or branched chain alkyl,etc.； R1 is hydrogen, C1-C6 linear or branched chain alkyl, etc.； R2 are independently hydrogen or C1-C6 linear or branched chain alkyl； R3 and R4 are independently hydrogen, C1-C6 linear or branched chain alkyl, etc；. R5and R6 are independently hydrogen or C1-C linear or branched chain alkyl, etc.； R8 is hydrogen, C1-C6 linear or branched chain alkyl, etc.； R9 and R10 are independently hydrogen or C1-C linear or branched chain alkyl, etc.； Q is --CO--, -- (CH2)q--, --(CHRs)q--, or (CRsR)q--, where Rs and R, are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl； where q is 0, 1, 2, or 3； and, where n is 0, 1, 2, 3, 4 or 5； or, a pharmaceutically acceptable salt thereof, for the treatment of certain diseases, particularly those affected or mediated by the androgen receptor； to compbinations comprising such compounds with a second pharmaceutically active ingredient； to compositions containing such combinations； and to such combinations for the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.
