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Treatment of renal disease symptoms with selective androgen receptor modulators (MRSA)
专利权人:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
发明人:
DALTON, JAMES T,MILLER, DUANE D.
申请号:
ES11185780
公开号:
ES2453981T3
申请日:
2006.08.28
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A selective androgen receptor modulator compound (MRSA) having the formula I: ** Formula ** wherein G is O or S; X is O; T is OH, OR, NHCOCH3 or NHCOR; Z is NO2, CN, COOH, COR, NHCOR or CONHR; Y is CF3, F, I, Br, Cl, CN, C (R) 3 or Sn (R) 3; Q is alkyl, halogen, CF3, CN, C (R) 3, Sn (R) 3, N (R) 2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR; or Q together with the benzene ring to which it is attached is a condensed ring system represented by structure A, B or C: R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen , alkenyl or OH; and R1 is CH3, CH2F, CHF2, CF3, CH2CH3 or CF2CF3 for use in the treatment, prevention, suppression, inhibition or reduction of the incidence of symptoms associated with kidney disease, wherein said symptoms associated with kidney disease are hypogonadism in kidney disease. , or where said renal disease is end-stage renal disease (ERT).Un compuesto modulador selectivo de receptor de andrógenos (SARM) que tiene la fórmula I:**Fórmula** en donde G es O o S; X es O; T es OH, OR, NHCOCH3 o NHCOR; Z es NO2, CN, COOH, COR, NHCOR o CONHR; Y es CF3, F, I, Br, Cl, CN, C(R)3 o Sn(R)3; Q es alquilo, halógeno, CF3, CN, C(R)3, Sn(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR; o Q junto con el anillo de benceno al que está unido es un sistema anular condensado representado por la estructura A, B o C: R es alquilo, haloalquilo, dihaloalquilo, trihaloalquilo, CH2F, CHF2, CF3, CF2CF3, arilo, fenilo, halógeno, alquenilo u OH; y R1 es CH3, CH2F, CHF2, CF3, CH2CH3 o CF2CF3 para usar en el tratamiento, prevención, supresión, inhibición o reducción de la incidencia de síntomas asociados con enfermedad renal, en donde dichos síntomas asociados con enfermedad renal son hipogonadismo en enfermedad renal, o en donde dicha enfermedad renal es
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