The invention relates pyridine amide derivative of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring； R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3； A is C or N； E is a group of formula (B) or (C), wherein B is C(O)OH, C(O)O(C1-C3)alkyl, and C is selected from the group consisting of formula (I) m is 1,2 or 3, n is 0 or 1, W is &mdash；O&mdash；, &mdash；O(C1-C3 alkyl)-； &mdash；(C1-C3 alkyl)O&mdash；； &mdash；C(O)&mdash；； &mdash；C(&boxH；N&mdash；O(C1-C3 alkyl))-； &mdash；NH&mdash； or &mdash；NH(C1-C3alkyl)-； Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, &mdash；NH(C1-C3alkyl)-； &mdash；N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is covalently bonded to Ar and optionally containing one or two heteroatoms selected from N, O and S； and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. The compounds of the invention could be used for manufacturing a medicament for the treatment of pathologies which require the use of an antagonist of the EP4 receptor, such as the treatment of acute and chronic pain, inflammatory pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid arthritis, cancer, endometriosis and migraine.L'invention concerne un dérivé de pyridinamide de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, dans lequel R1 et R2 sont indépendamment un hydrogène, un alkyle en C1-C3 linéaire ou ramifié ou assemblés conjointement ils forment un cycle cyclopropyle； R est indépend
