PROBLEM TO BE SOLVED: To provide a commercial mass-production method for consistently obtaining a fixed amount of an active substance-containing material containing 1-deoxynojirimycin and polyphenols.SOLUTION: Chips are obtained when mulberry twigs with ≤8 cm diameter are gathered within one month after collecting mulberry leaves, and then, dried at ≤75°C within 48 hours. The chips are pulverized into fine powder with average particle size of 60 microns. In this way, without performing any complicated extracting operation on the mulberry twigs after mulberry leaves collection, the fine powder showing stable glucose absorption inhibiting effect is obtained. The obtained mulberry twig fine powder has blood glucose level increase inhibitory effect and insulin increase inhibitory effect, which show postcibal blood glucose level improving effect equal to a diabetic postcibal hyperglycemia improvement agent, and is usable as a diabetes mellitus prevention agent and a diabetes mellitus therapeutic agent.COPYRIGHT: (C)2013,JPO&INPIT【課題】常に一定した量の1-デオキシノジリマイシン及びポリフェノール類を含む活性物質含有素材を商業ベースで大量に取得する方法の提供。【解決手段】桑葉採取後1ヶ月以内に桑幹径8cm以下の小枝を採取、48時間以内に75℃以下で乾燥したチップを平均粒子60ミクロンに粉砕した微粉末。【効果】桑葉採取後の桑小枝に煩雑なエキス抽出操作を行うことなく、安定した糖吸収抑制作用効果を示す微粉末が得られる。得られる桑小枝微粉末の血糖値上昇抑制作用及びインスリン上昇抑制作用は糖尿病食後過血糖改善剤(ベイズイン)と同じ食後の血糖改善作用を示し、糖尿病予防および糖尿病治療剤としての有用性が認められる。【選択図】なし
