Zepp, Charles,Gao, Yun,Keegan, Mark J.,Baldwin, Sam,Fu, Fen-ni,Johnston, Lloyd,Lipford, Grayson B.
申请号：
AU2016200137
公开号：
AU2016200137A1
申请日:
2016.01.11
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016200137A120160204.pdf#####Abstract This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. See Fig 1.WO 2010/138193 PCT/US2010/001560 1/7 % R848 Release (All) PBS, 37C 100.00 0 80.00 Z 50.00 U 2 C 40.00 4 . 20.00 I' 5 0.00 0 20 40 60 80 100 120 7 Hours FIG. 1 % R848 Release (All) Citrate, pH 4.5, 37C 120.00 100.00 9 0.00 *-W 2 60.00 ± 3 S40.00 ,' 04 0.00 5 0 20 40 60 80 100 120 - 6 Hours 7 FIG. 2
