#$%^&*AU2020227055A120200917.pdf#####ABSTRACT A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 16532655_1 (GHMatters) P77900.AU.419/22 t=100% I L ccI LuII t~ =0 'm AUTO-AMPUTATION IE ~NECROTIC FOOT 60%' MULTIPLE NECROTICTOES m1 240%I I ONE NECROTICTOE 40 I TIPSOF TOES (BLACK) IL II o NORMAL O ~ ~ ~ ~ 6 1 2 4 61 24 1 2 4 61 2 4 6124 TIME (eeks) SCAFFOLD；SCAFFOLD iSCAFFOLDi BOLUS BLANK EPC+OEC 1EPC OEC EPC+OEC SCAFFOLD Fig. 13D
