VITE, GREGORY,GAVAI, ASHVINIKUMAR,FINK, BRIAN,MASTALERZ, HAROLD,KADOW, JOHN
申请号：
ES03813396
公开号：
ES2374393T3
申请日:
2003.12.12
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula 1 in which: R is selected from the group consisting of aryl, substituted aryl, heterocycle and substituted heterocycle； R1 is selected from the group consisting of alkyl and substituted alkyl； R2 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl, heterocycle and substituted heterocycle； or R2 may be absent； X is selected from the group consisting of a bond, O, S, C (R3) 2, C (R3) 3, NR3, and N (R3) 2； and R3 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, heterocycle and substituted heterocycle； wherein the substituted alkyl is substituted with one to four substituents, each substituent being independently selected from the group consisting of halo； hydroxy； alkoxy； oxo； alkanoyl； aryloxy； alkanoyloxy； Not me； alkylamino； arylamino； aralkylamino； disubstituted amino, wherein the amino substituents are independently selected from alkyl, aryl and aralkyl； alkanoylamino； aroylamino； aralkanoylamino； substituted alkanoylamino； substituted arylamino； substituted aralkanoylamino； thiol； alkylthio； arylthio； aralkylthio； alkylthion； aryltiono； aralkylthio； alkylsulfonyl； arylsulfonyl； aralkylsulfonyl； sulfonamido； substituted sulfonamido； nitro； cyano； carboxy； carbamilo； substituted carbamyl, in which the substituents in the nitrogen are independently selected from alkyl, aryl and aralkyl； CONHalkyl； CONHarilo； CONHaralkyl； alkoxycarbonyl； aryl； substituted aryl； guanidino； heterocycle； and substituted heterocycle； wherein each substituents is optionally further substituted with alkyl, alkoxy, aryl or aralkyl； wherein the substituted cycloalkyl is substituted with one or more substituents, each substituent being independently selected from the group consisting of halo； hydroxy； alkoxy； oxo； alkanoyl； aryloxy； alkanoyloxy； Not me； alkylamino； arylamino； aralkylamino； disubstituted am
