The present invention provides a derivative of a pharmaceutically acceptable salt thereof or a thereof, or compounds of formula (I) Is selected from the group consisting of optionally substituted heteroaryl and optionally substituted heteroaryl, and alkyl optionally substituted aryl, optionally substituted aryl alkyl, optionally substituted wherein, R 1 is optionally substituted R 2 hydrogen, halogen, hydroxyl, alkoxy, aryloxy, R3 may be substituted are selected from the group consisting of optionally sulfamoyl and optionally substituted sulfonyl and good acyl, optionally substituted may be substituted is selected from the group consisting of nitrile or aminosulfonyl good good aminocarbonyl, can be optionally substituted amino, optionally substituted alkyl, optionally substituted X1 is a chemical bond, CR 7 R 8, C (= O C (= NH), NR 9, NHC (= O), and is selected from the group consisting of SO 2,) substituted alkyl, R 8 and R 7 is substituted independently represent a hydrogen, an optionally substituted or, R 8 and R 7 are both cycloalkyl ring optionally C 4-6 can be substituted heteroaryl which may be substituted, and aryl which may be cycloalkyl, optionally substituted be form R 9 is is selected from the group consisting of optionally substituted heteroaryl and optionally substituted aryl and optionally substituted alkyl, optionally substituted hydrogen, optionally substituted or saturated A may be substituted formula that was partially saturated or represents a 4-7 membered ring represented by the formulaX 3 Yes C (R 5a) 2, NH, N (R 5b), with S or O C independently each X 4 (= CH or N to X 2 in each selected from R 4a and R 4b is preferably amino, hydroxyl and independently, halogen, optionally substituted selected N O), CH 2, CH or (R 4a), (R 4a) from (R 4b) an aryl substituted aryl alkyl, optionally substituted cycloalkyl, and optionally substituted alkyl, optionally substituted aryloxy, which may be substituted alkoxy, optionally substituted substituted an alko
