METHOD FOR MAKING 3A-HYDROXY&NBSP 3ß- METHYL-5A-PREGNAN-20-ONE (GANAXOLONE)

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专利权人:

发明人:

SHAW KENNETH,HUTCHISON ALAN

申请号：

IN312/MUMNP/2012

公开号：

IN2012MN00312A

申请日:

2012.02.07

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

METHOD FOR MAKING 3α-HYDROXY, 3β-METHYL-5α-PREGNAN-20-ONE (GANAXOLONE) Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α- pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione with an organometallic methylating agent in an inert solvent to provide a compound of the formula. Figure 1 is the representative figure.

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