Method for making 3alpha-hydroxy, 3beta- methyl-5alpha-pregnan-20-one (ganaxolone)

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专利权人:

Marinus Pharmaceuticals; Inc.

发明人:

Shaw, Kenneth,Hutchison, Alan

申请号：

AU2010282570

公开号：

AU2010282570B2

申请日:

2010.08.11

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α- pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione； with an organometallic methylating agent in an inert solvent to provide a compound of the formula.

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