KAHRAMAN, MEHMET,BOREN, BRANT CLAYTON,SLEE, DEBORAH HELEN,BUNKER, KEVIN DUANE,PINCHMAN, JOSEPH ROBERT,HOPKINS, CHAD DANIEL
申请号：
ARP180101265
公开号：
AR111792A1
申请日:
2018.05.14
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
This compound and its use as an analgesic are described in this document. 1. Claim 1: a compound (1) selected from the formula group compound,There, every x1,Every lastEvery X3Per X83088,Per X83099,Every x 8310xy,Per X8311,Each X1,Every secondcada X y cada X es independientemente hidr geno deuterio un alquilo C no sustituido fl or o cloro siempre y cuando al menos dos de X sean fl or o cloro siempre y cuando al menos dos de X sean fl or o cloro siempre y cuando al menos 1. The condition is that fluorine or chlorine is at least 2x1 cubic meters, and fluorine or chlorine is at least 2x1 830808； per x831222；each X⁹ and X¹⁰ is independently of deuterium, fluorine or chlorine； R¹ is an unsubstituted a-amino acid； R² and R³ are independently an unsubstituted C₁₋₄ alkyl； R⁹ᵃ and R⁹ᵇ are independently an unsubstituted C₁₋₄ alkyl； R⁵A, R⁵B, R⁵D, R⁵E, R⁵F, R⁵G, R⁵H, R⁵J, R⁵K and R⁵L are independently hydrogen, deuterium or an unsubstituted C₁₋₄ alkyl； R⁵C is selected from the group consisting of hydrogen, deuterium, an unsubstituted C₁₋₄ alkyl and C (= O) R¹²；R⁴ᵃ and R⁴ᵇ are independently deuterium, an unsubstituted C₁₋₄ alkyl, a substituted C₁₋₄ hydroxyl alkyl or -C (X¹⁶) ₃,a. Provided that there is at least one r8308； 7491 and r8308； 7495sea-c (x1 8310a) 8323；R8310,R831111 and r831222 are independent - (ch832222)；R¹⁰ is selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, an unsubstituted C₁₋₈ alkyl, an unsubstituted C₃₋₂₀ cycloalkyl and an unsubstituted C₁₋₈ haloalkyl； R¹¹ is selected from the group consisting of hydrogen, deuterium, halogen, an unsubstituted C₁₋₃₀ alkyl, an unsubstituted C₂₋₃₀ alkenyl and an unsubstituted C₁₋₈ haloalkyl； R¹² is selected from the group consisting of hydrogen, deuterium, an unsubstituted C₁₋₃₀ alkyl and an unsubstituted C₂₋₃₀ alkenyl； each X¹⁶ is independently hydrogen, deuterium, an unsubstituted C₁₋₄ alkyl, fluorine or chlorine,Provided that at least two X1 8310 are fluorine or chlorine； Z1,P8 P8 P8 P8 P8 P8 P8 P8
