Hui Ding,Julia Y. Ljubimova,Eggehard Holler,Keith L. Black
申请号：
US13646947
公开号：
US08795648B2
申请日:
2012.10.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Polycefin-LLL includes drug antisense morpholino oligos, targeting antibodies, and a pH-sensitive endosome escape unit. In addition, the drug could be siRNA, microRNA, and aptamer.
