DING, HUI,LJUBIMOVA, JULIA, Y.,HOLLER, EGGEHARD,BLACK, KEITH, L.
申请号：
EP09730249
公开号：
EP2271368A4
申请日:
2009.04.10
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Polycefin-LLL includes drug antisense morpholino oligos, targeting antibodies, and a pH-sensitive endosome escape unit. In addition, the drug could be siRNA, microRNA, and aptamer.
