POLY(BETA MALIC ACID) WITH PENDANT LEU-LEU-LEU TRIPEPTIDE FOR EFFECTIVE CYTOPLASMIC DRUG DELIVERY

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专利权人:

Cedars-Sinai Medical Center

发明人:

申请号：

EP09730249.1

公开号：

EP2271368B1

申请日:

2009.04.10

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Polycefin-LLL includes drug antisense morpholino oligos, targeting antibodies, and a pH-sensitive endosome escape unit. In addition, the drug could be siRNA, microRNA, and aptamer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/