PROBLEM TO BE SOLVED: To provide a method for decreasing an expression of CD36 by a cell.SOLUTION: The method includes a step of placing the cell in contact with an effective amount of the aromaticity cation peptide having the following behaviors: at least one net positive charge four amino acids at a minimum about twenty amino acids at a maximum a relation that 3p m is a maximum number of r+1 or less between a minimum number (p m) of net positive charge and a total amino acid residue (r) and a relation that 2a is a maximum number of pt+1 or less between a minimum number (a) of aromatic group and a total net positive charge (p t), but when a is 1, p t can also be1.COPYRIGHT: (C)2013,JPO&INPIT【課題】本発明は、細胞でCD36の発現を減少させる方法を提供する。【解決手段】本発明の方法は、以下の性質を有する芳香族性陽イオンペプチドの有効量と細胞を接触させることを含む:少なくとも1つの正味の陽電荷;最小限4つのアミノ酸;最大限約20のアミノ酸;正味の陽電荷の最小数(pm)とアミノ酸残基総数(r)との間で、3pmがr+1以下の最大の数であるという関係;及び芳香族基の最小数(a)と正味の陽電荷の総数(pt)との間で、2aはpt+1以下の最大数であるが、aが1のときはptもまた1でありえる関係。【選択図】なし
